The first thing you should know when making your decision on who should be your best man is to not feel bad about your final decision. Not all of your male friends/cousins/siblings can be your best man, so don't feel bad when you have to choose.
Write a list of who are the top contenders. Near their name, write qualities that you feel your best man should have.
Talk to someone else about your choices, especially someone who you feel can make good decisions.
Choose the most responsible one since the best man will have his own responsibilities to attend to. (Look in the Responsibilities section of the article and see who can do these jobs well.)
If you really don't know, just let your friends decide as to who should be the best man.
If you still can't decide, you may even consider having best men.